The authors thank Marianna Jacob, Mark Anderson, Caryn Sefton and Sheila Harney. This research was supported by NIH grants RO1 CA 46627-08, PO1 CA67165-01A1, PO1 AG04953-14, NSF grants BES 9631710 and DARPA grant F41624-96-2-0001. It was also supported by the Boston Neurosurgical Foundation.